Cinnamon (Cinnamomum cassia) hot water extract improves inflammation and tight junctions in the intestine in vitro and in vivo

Abstract The natural byproduct Cinnamomum cassia was widely used in ancient Asia to cure disease because of its various pharmacological effects. Despite ethnomedicinal benefits, few studies on the intestinal anti-inflammatory effect C. have been reported. Therefore, this study aimed evaluate potential beneficial effects intestine vitro and vivo. Herein, cinnamon hot water extract (CWE) tight junction (TJ) barrier function, transepithelial electrical resistance, mRNA expression were confirmed Caco-2 cells. CWE treatment groups showed significantly enhanced cell permeability, proinflammatory cytokine expression, TJ expression. CWE-treated mice an improved histological index decreased concentrations compared with those colitis model mice. These results suggest that alleviated inflammatory damage barrier, indicating may be as a functional food improve health.